光动力疗法
光敏剂
纳米棒
卟啉
单线态氧
材料科学
系统间交叉
光毒性
纳米技术
堆积
光化学
纳米颗粒
化学
单重态
有机化学
生物化学
物理
氧气
核物理学
体外
激发态
作者
Lijun Yang,Yanqiu Li,Xiaorui Ren,Rong Jia,Lulu Si,Jianshuai Bao,Yingying Shi,Jiajie Sun,Yong Zhong,Peng‐Cheng Duan,Xiaoyan Yang,Rui Zhu,Yu Jia,Feng Bai
出处
期刊:ACS Nano
[American Chemical Society]
日期:2024-01-16
标识
DOI:10.1021/acsnano.3c09399
摘要
Designing and constructing supramolecular photosensitizer nanosystems with highly efficient photodynamic therapy (PDT) is vital in the nanomedical field. Despite recent advances in forming well-defined superstructures, the relationship between molecular arrangement in nanostructures and photodynamic properties has rarely been involved, which is crucial for developing stable photosensitizers for highly efficient PDT. In this work, through a microemulsion-assisted self-assembly approach, indium porphyrin (InTPP) was used to fabricate a series of morphology-controlled self-assemblies, including nanorods, nanospheres, nanoplates, and nanoparticles. They possessed structure-dependent 1O2 generation efficiency. Compared with the other three nanostructures, InTPP nanorods featuring strong π–π stacking, J-aggregation, and high crystallinity proved to be much more efficient at singlet oxygen (1O2) production. Also, theoretical modeling and photophysical experiments verified that the intermolecular π–π stacking in the nanorods could cause a decreased singlet–triplet energy gap (ΔEST) compared with the monomer. This played a key role in enhancing intersystem crossing and facilitating 1O2 generation. Both in vitro and in vivo experiments demonstrated that the InTPP nanorods could trigger cell apoptosis and tumor ablation upon laser irradiation (635 nm, 0.1 W/cm2) and exhibited negligible dark toxicity and high phototoxicity. Thus, the supramolecular self-assembly strategy provides an avenue for designing high-performance photosensitizer nanosystems for photodynamic therapy and beyond.
科研通智能强力驱动
Strongly Powered by AbleSci AI