器官系统
人类健康
细胞代谢
器官功能障碍
混淆
炎症
免疫系统
毒性
生物
生物信息学
医学
生理学
环境卫生
新陈代谢
免疫学
病理
生物化学
疾病
内科学
败血症
作者
Nurshad Ali,Jenny Katsouli,Emma L. Marczylo,Timothy W. Gant,Sarah Wright,Jorge Bernardino de la Serna
出处
期刊:EBioMedicine
[Elsevier]
日期:2024-01-01
卷期号:99: 104901-104901
被引量:2
标识
DOI:10.1016/j.ebiom.2023.104901
摘要
Humans are exposed to micro-and-nano plastics (MNPs) through various routes, but the adverse health effects of MNPs on different organ systems are not yet fully understood. This review aims to provide an overview of the potential impacts of MNPs on various organ systems and identify knowledge gaps in current research. The summarized results suggest that exposure to MNPs can lead to health effects through oxidative stress, inflammation, immune dysfunction, altered biochemical and energy metabolism, impaired cell proliferation, disrupted microbial metabolic pathways, abnormal organ development, and carcinogenicity. There is limited human data on the health effects of MNPs, despite evidence from animal and cellular studies. Most of the published research has focused on specific types of MNPs to assess their toxicity, while other types of plastic particles commonly found in the environment remain unstudied. Future studies should investigate MNPs exposure by considering realistic concentrations, dose-dependent effects, individual susceptibility, and confounding factors.
科研通智能强力驱动
Strongly Powered by AbleSci AI