药物发现
化学
计算生物学
小分子
新颖性
鉴定(生物学)
透视图(图形)
配体(生物化学)
表型筛选
组合化学
纳米技术
计算机科学
生物化学
受体
基因
生物
表型
人工智能
哲学
植物
神学
材料科学
作者
Gavin W. Collie,Matthew Clark,Anthony D. Keefe,Andrew Madin,Jon Read,Emma L. Rivers,Ying Zhang
标识
DOI:10.1021/acs.jmedchem.3c01861
摘要
The DNA-encoded library (DEL) discovery platform has emerged as a powerful technology for hit identification in recent years. It has become one of the major parallel workstreams for small molecule drug discovery along with other strategies such as HTS and data mining. For many researchers working in the DEL field, it has become increasingly evident that many hits and leads discovered via DEL screening bind to target proteins with unique and unprecedented binding modes. This Perspective is our attempt to analyze reports of DEL screening with the purpose of providing a rigorous and useful account of the binding modes observed for DEL-derived ligands with a focus on binding mode novelty.
科研通智能强力驱动
Strongly Powered by AbleSci AI