Alopecia areata and thyroid screening in Down syndrome: Leveraging epic cosmos data set

Individuals with Down syndrome (DS) are at an increased risk of numerous autoimmune conditions, most commonly autoimmune hypothyroidism.1 This association is likely to be secondary to complex immune dysregulation caused by trisomy of chromosome 21, in particular the autoimmune regulator gene and interferon dysfunction. Alopecia areata (AA) is reportedly more common in people with DS, but prevalence studies are limited, with figures varying from 1.3% to 11% compared with 0.1% to 0.2% in the general population.