鸟嘌呤核苷酸交换因子
人类疾病
功能(生物学)
生物信息学
领域(数学分析)
RAC1
机制(生物学)
神经科学
计算生物学
生物
遗传学
心理学
认知科学
基因
信号转导
认识论
哲学
数学
数学分析
作者
Erin Fingleton,Katherine W. Roche
标识
DOI:10.1016/j.tins.2023.03.004
摘要
In a recent study, Bonnet and colleagues leveraged in silico structure prediction and human genetic data to understand the molecular regulation of the Rac1-activating guanie nucleotide exchange factor (Rac1-GEF) domain of Trio. Their work sheds new light on the role of Trio during axon guidance and explores the mechanism by which Trio GEF function is regulated in health and dysregulated in disease.
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