Perioperative Radiotherapy and Survival After Surgical Treatment of Nonmetastatic Retroperitoneal Sarcoma

The rate of perioperative RT use was lowest in well-differentiated retroperitoneal liposarcoma. Conversely, perioperative RT was used at approximately twice that rate in dedifferentiated liposarcoma and leiomyosarcoma. These findings are discordant with the most recent guideline recommendations but should be interpreted in the context of the historical nature of the investigated cohort, which predates the publication of those guidelines. Perioperative RT was not associated with differences in cancer-specific mortality across any of the 3 examined retroperitoneal sarcoma histologic subtypes. Unfortunately, local recurrence, surgical margin status, and metastatic progression rates could not be addressed.