S913 phosphorylation of Ulk1 protects the heart from aging through inhibition of cardiac senescence

The chS913A mice exhibit premature cardiac aging, which is mediated through stimulation of cardiomyocyte senescence. The results support the role of the GSK-3β-Ulk1-autophagy pathway in the heart during aging. Thus, these mice could be useful in studying cardiac aging and senescence.