Calcium Phosphate Nanoparticle‐Immobilized Macrophage‐Derived Extracellular Vesicle Nanohybrid Facilitates Diabetic Bone Regeneration

-Akt signaling axis. In vivo, hydrogel-assisted delivery of M2EV@CaP significantly promotes bone regeneration in diabetic rat calvarial defects through immunomodulation and osteoinduction. This study proposes a nanohybridization strategy based on inorganic nanoparticles reinforcing biostructures, offering a promising extracellular vesicle therapy for complex pathological conditions.