医学
推车
淋巴瘤
人类免疫缺陷病毒(HIV)
临床试验
免疫系统
免疫学
发病机制
入射(几何)
人口
抗逆转录病毒疗法
重症监护医学
生物信息学
内科学
病毒载量
生物
环境卫生
机械工程
物理
光学
工程类
作者
Riccardo Dolcetti,Emanuela Vaccher,Antonino Carbone
出处
期刊:Cancers
[Multidisciplinary Digital Publishing Institute]
日期:2025-06-22
卷期号:17 (13): 2088-2088
标识
DOI:10.3390/cancers17132088
摘要
Although efficiently managed by cART, chronic HIV infection remains associated with a high incidence of malignant lymphomas. This diverse group of tumors presents considerable challenges in research, diagnosis, and treatment due to their complex pathogenesis, heterogeneous tumor microenvironment, and frequently aggressive clinical behavior. In this review, we examine the multifactorial pathogenesis of lymphomas arising in people living with HIV (PLWH), encompassing both direct and indirect oncogenic mechanisms. We summarize the key histopathological features and microenvironmental characteristics that may influence therapeutic responses. Current treatment strategies approved for the treatment of lymphomas in PLWH are showing outcomes comparable with those observed in patients without HIV. Notably, the immune reconstitution achieved through cART has renewed interest in immunotherapeutic approaches for HIV-associated lymphomas, with several strategies under clinical investigation. However, progress in the diagnosis and management of these malignancies is hindered by fragmented research efforts and the frequent exclusion of PLWH from pivotal clinical trials. Coordinated efforts are essential to overcome these barriers, reduce lymphoma incidence, and improve survival outcomes in this vulnerable population.
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