An integrated approach of experiment validation and single-cell RNA sequencing reveal dual-pathway inhibition of NLRP3/ferroptosis by flavonoids of Sanyeqing fibrous root in acute lung injury

SYQfr-F ameliorates ALI by concurrently inhibiting NLRP3 inflammasome activation and ferroptosis, validating the traditional use of SYQ in respiratory disorders and highlighting its fibrous roots as a novel therapeutic resource.