间充质干细胞
急性呼吸窘迫综合征
脐带
生物
干细胞
移植
肺
免疫学
癌症研究
医学
病理
内科学
细胞生物学
作者
Yujuan Wang,Lei Han,Xue Li,Xin Su,Xiao Han,Junling Yang
出处
期刊:Stem Cells and Development
[Mary Ann Liebert]
日期:2021-02-01
卷期号:30 (3): 128-134
被引量:8
标识
DOI:10.1089/scd.2020.0174
摘要
Acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) is a severe clinical respiratory failure disorder associated with chronic pathology and disability and has a mortality rate of 40%-60%. However, the pathogenesis of ARDS/ALI remains unclear, and existing therapeutic options are insufficient for addressing the severity of the disease. Mesenchymal stem cells (MSCs) play an important role in the prevention and treatment of ALI, especially acute alveolar epithelial injury. However, the low survival rate of transplanted MSCs reduces their effectiveness. When human umbilical cord MSCs (hUC-MSCs) are transplanted directly, only a minority of cells migrate toward damaged tissues. Moreover, their maintenance time is short, leading to unsatisfactory therapeutic results. A moderate hypoxic environment can promote the proliferation of MSCs, inhibit apoptosis, and facilitate migration and chemotaxis. In summary, hypoxic culturing before transplantation improves the effectiveness of hUC-MSCs in treating ARDS/ALI and promises to provide novel diagnostic and therapeutic targets.
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