GPX4
脂质过氧化
生发中心
细胞生物学
磷脂过氧化氢谷胱甘肽过氧化物酶
生物
细胞
化学
谷胱甘肽
谷胱甘肽过氧化物酶
免疫学
B细胞
生物化学
抗体
氧化应激
酶
作者
Jonathan Muri,Helen Thut,Georg W. Bornkamm,Manfred Köpf
出处
期刊:Cell Reports
[Elsevier]
日期:2019-11-01
卷期号:29 (9): 2731-2744.e4
被引量:104
标识
DOI:10.1016/j.celrep.2019.10.070
摘要
Aerobic organisms need to maintain cellular redox homeostasis. Glutathione peroxidase-4 (Gpx4) has the unique ability to protect cells against lipid peroxidation. Here, we show that Gpx4 is absolutely required to prevent ferroptosis during development, maintenance, and responses of innate-like B cells, namely, the B1 and marginal zone (MZ) B cells. In contrast, Gpx4 is dispensable for the development, germinal center reactions, and antibody responses of follicular B2 cells. Mechanistically, we show increased lipid metabolism and sensitivity to lipid peroxidation and ferroptosis in B1 and MZ B cells compared to follicular B2 cells, consistent with the requirement of Gpx4 in innate-like B cells. This high sensitivity to ferroptosis of innate-like B cells may be used to therapeutically target Gpx4 in certain forms of B cell malignancies involving B1 cells.
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