We demonstrate for the first time, to our knowledge, the occurrence of a sixth -order exceptional point of degeneracy (EPD) in a realistic multimode optical photonic structure by using a modified periodic coupled-resonator optical waveguide (CROW) at the optical wavelength λe=1550nm . The sixth-order EPD is obtained in a CROW without the need of loss or gain, and such an EPD corresponds to a very special band edge of the periodic photonic structure where six eigenmodes coalesce, so we refer to it as the sixth-order degenerate band edge (6DBE). Moreover, we report a new scaling law of the quality factor Q of an optical cavity made of such a periodic 6DBE-CROW with cavity length as Q∝N7 , when operating near the 6DBE with N being the number of unit cells in the periodic finite-length CROW. Furthermore, we elaborate on the application of the 6DBE to ultralow-threshold lasers. We present a novel scaling law of the lasing threshold that scales as N−7 when operating near the 6DBE. Also, we show the superiority of the threshold scaling of the 6DBE-CROW to the scaling of another CROW with the same size operating near a fourth-order EPD that is often referred to as the degenerate band edge (DBE). The lasing threshold scaling of the DBE-CROW laser is shown here for the first time to our knowledge. We also discuss the high sensitivity of the proposed 6DBE-CROW to perturbations, which may find applications in sensors, modulators, optical switches, nonlinear devices, and Q -switching cavities.