免疫学
肺炎链球菌
人口
免疫
微生物学
肺
免疫系统
医学
巨噬细胞
肺泡巨噬细胞
单核细胞
生物
体外
内科学
抗生素
环境卫生
生物化学
作者
Helena Aegerter,Justina Kulikauskaite,Stefania Crotta,Harshil Patel,Gavin Kelly,Edith M. Hessel,Matthias Mack,Sören Beinke,Andreas Wack
标识
DOI:10.1038/s41590-019-0568-x
摘要
Despite the prevalence and clinical importance of influenza, its long-term effect on lung immunity is unclear. Here we describe that following viral clearance and clinical recovery, at 1 month after infection with influenza, mice are better protected from Streptococcus pneumoniae infection due to a population of monocyte-derived alveolar macrophages (AMs) that produce increased interleukin-6. Influenza-induced monocyte-derived AMs have a surface phenotype similar to resident AMs but display a unique functional, transcriptional and epigenetic profile that is distinct from resident AMs. In contrast, influenza-experienced resident AMs remain largely similar to naive AMs. Thus, influenza changes the composition of the AM population to provide prolonged antibacterial protection. Monocyte-derived AMs persist over time but lose their protective profile. Our results help to understand how transient respiratory infections, a common occurrence in human life, can constantly alter lung immunity by contributing monocyte-derived, recruited cells to the AM population.
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