亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Kaempferol protects against cadmium chloride-induced hippocampal damage and memory deficits by activation of silent information regulator 1 and inhibition of poly (ADP-Ribose) polymerase-1.

海马结构 海马体 DNA损伤 药理学 细胞生物学 活性氧 活力测定 NMDA受体 程序性细胞死亡 超氧化物歧化酶 丙二醛
作者
Attalla F. El-kott,Abd-El-karim Mohamed Abd-Lateif,Heba S. Khalifa,Kareem Morsy,Essam H. Ibrahim,May Bin-Jumah,Mohamed M. Abdel-Daim,Lotfi Aleya
出处
期刊:Science of The Total Environment [Elsevier]
卷期号:728: 138832- 被引量:19
标识
DOI:10.1016/j.scitotenv.2020.138832
摘要

Abstract The neuroprotective effect of Kaempferol against cadmium chloride (CdCl2) -induced neurotoxicity is well reported. The silent information regulator 1 (SIRT1) and poly (ADP-Ribose) polymerase-1 (PARP1) are two related cellular molecules that can negatively affect the activity of each other to promote or inhibit cell survival, respectively. It is still largely unknown if the neurotoxicity of CdCl2 or the neuroprotection of Kaempferol are mediated by modulating SIRT1 and/or PAPR1 activities. In this study, we tested the hypothesis that CdCl2-induced memory deficit and hippocampal damage are associated with downregulation/inhibition of SIRT1 and activation of PAPR1, an effect that can be reversed by co-treatment with Kaempferol. Rats (n = 12/group) were divided into 4 groups as control, control + Kaempferol (50 mg//kg), CdCl2 (0.5 mg/kg), and CdCl2 + Kaempferol. All treatments were administered orally for 30 days daily. As compared to control rats, CdCl2 reduced rat's final body weights (21.8%) and their food intake (30%), induced oxidative stress and apoptosis in their hippocampi, and impaired their short and long-term recognition memory functions. Besides, the hippocampi of CdCl2-treated rats had higher levels of TNF-α (197%), and IL-6 (190%) with a concomitant increase in nuclear activity and levels of NF-κB p65 (721% & 554%). Besides, they showed reduced nuclear activity (53%) and levels (74%) of SIRT1, higher nuclear activity and levels of PARP1 (292% & 138%), increased nuclear levels of p53 (870%), and higher acetylated levels of NF-κB p65 (513%), p53 (644%), PARP1 (696%), and FOXO-2 (149%). All these events were significantly reversed in the CdCl2 + Kaempferol-treated rats. Of note, Kaempferol also increased levels of MnSOD (73.5%), and GSH (40%), protein levels of Bcl-2 (350%), and nuclear activity (67%) and levels (46%) of SIRT1 in the hippocampi of the control rats. In conclusion, Kaempferol ameliorates CdCl2-induced memory deficits and hippocampal oxidative stress, inflammation, and apoptosis by increasing SIRT1 activity and inhibiting PARP1 activity.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Rin发布了新的文献求助10
刚刚
9秒前
49秒前
Rigel完成签到,获得积分10
59秒前
Rigel发布了新的文献求助10
1分钟前
Flexy发布了新的文献求助10
1分钟前
Flexy发布了新的文献求助10
1分钟前
科研通AI2S应助Flexy采纳,获得10
2分钟前
欢喜的慕青完成签到 ,获得积分10
2分钟前
昵称完成签到 ,获得积分10
2分钟前
江湖小妖完成签到 ,获得积分10
4分钟前
4分钟前
俏皮诺言完成签到,获得积分10
4分钟前
messi发布了新的文献求助30
4分钟前
星辰大海应助海燕采纳,获得30
5分钟前
Ji完成签到 ,获得积分10
5分钟前
messi发布了新的文献求助10
5分钟前
messi发布了新的文献求助10
5分钟前
6分钟前
7分钟前
桐桐应助孤独的钻石采纳,获得10
7分钟前
8分钟前
8分钟前
白云朵儿发布了新的文献求助10
8分钟前
852应助ach采纳,获得10
8分钟前
海燕发布了新的文献求助30
8分钟前
孤独的钻石完成签到,获得积分10
8分钟前
Cynthia完成签到 ,获得积分10
8分钟前
21完成签到 ,获得积分10
9分钟前
9分钟前
shunzi发布了新的文献求助10
9分钟前
trap1完成签到 ,获得积分10
9分钟前
10分钟前
海燕发布了新的文献求助30
10分钟前
11分钟前
伍美华发布了新的文献求助10
11分钟前
毓香谷的春天完成签到 ,获得积分10
11分钟前
12分钟前
ach发布了新的文献求助10
12分钟前
CodeCraft应助ach采纳,获得10
12分钟前
高分求助中
Un calendrier babylonien des travaux, des signes et des mois: Séries iqqur îpuš 1036
Sustainable Land Management: Strategies to Cope with the Marginalisation of Agriculture 1000
Corrosion and Oxygen Control 600
Heterocyclic Stilbene and Bibenzyl Derivatives in Liverworts: Distribution, Structures, Total Synthesis and Biological Activity 500
重庆市新能源汽车产业大数据招商指南(两链两图两池两库两平台两清单两报告) 400
Division and square root. Digit-recurrence algorithms and implementations 400
行動データの計算論モデリング 強化学習モデルを例として 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2545595
求助须知:如何正确求助?哪些是违规求助? 2175642
关于积分的说明 5600185
捐赠科研通 1896371
什么是DOI,文献DOI怎么找? 946248
版权声明 565371
科研通“疑难数据库(出版商)”最低求助积分说明 503557