阿霉素
超声波
吲哚青绿
纳米颗粒
双模
材料科学
碳酸钙
对偶(语法数字)
荧光寿命成像显微镜
碳酸盐
生物医学工程
钙
超声成像
回声
纳米技术
荧光
医学
放射科
化疗
病理
外科
光学
航空航天工程
物理
工程类
作者
Haifeng Huang,Wenjing Zhang,Zhe Liu,Hongqian Guo,Ping-Yang Zhang
出处
期刊:Ultrasonics
[Elsevier]
日期:2020-12-01
卷期号:108: 106198-106198
被引量:6
标识
DOI:10.1016/j.ultras.2020.106198
摘要
Contrast-enhanced ultrasound (CEUS) is widely applied in cancer diagnosis clinically. However, the gas-filled contrast agents are unstable in the blood and exhibit shorter imaging time, which limit their clinical use. In this study, a diagnostic nanoparticle system was developed for dual-mode imaging (ultrasound and fluorescence), which after encapsulation with doxorubicin (DOX) demonstrated simultaneous therapeutic function towards cancer treatment. Thus, calcium carbonate (CaCO3) nanoparticles were encapsulated with doxorubicin (DOX) to obtain CaCO3-DOX. Under acidic conditions, it produced carbon dioxide (CO2) to enhance ultrasound imaging and increase the release of DOX. After intravenously injecting CaCO3-DOX to tumor-bearing mice, in the presence of an ultrasound field, CO2bubbles were sufficiently generated at the tumor tissues for echogenic reflectivity. Also, the indocyanine green (ICG) was encapsulated into CaCO3 nanoparticles, to further detect the tumor with fluorescence. The resultant theranostic nanoparticle system exhibited therapeutic efficacy towards tumour-bearing mice. Overall, this investigation provides an attractive strategy for dual-mode cancer diagnostics.
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