荧光
淀粉样蛋白(真菌学)
临床前影像学
淀粉样β
荧光寿命成像显微镜
生物物理学
β淀粉样蛋白
β淀粉样蛋白
材料科学
人脑
作者
Jian Wu,Chenwen Shao,Xiaolian Ye,Xiaojiao Di,Dongdong Li,Hu Zhao,Bing Zhang,Guiquan Chen,Hong-Ke Liu,Yong Qian
出处
期刊:ACS Sensors
[American Chemical Society]
日期:2021-01-13
卷期号:6 (3): 863-870
被引量:2
标识
DOI:10.1021/acssensors.0c01914
摘要
Abnormal accumulation of amyloid-β (Aβ) has been determined to be a critical factor for the progression of Alzheimer's disease (AD), which has motivated the development of new chemical approaches for early sensing and imaging of these Aβ aggregates. Herein, we report a new near-infrared (NIR) fluorescent probe for the selective monitoring of Aβ aggregates in vivo. This novel fluorophore, named CAQ, was based on the curcumin scaffold and was designed by introducing an intramolecular rotation donor and a quinoline functional group. CAQ was an environment-sensitive fluorescent probe that can be used as a reliable chemical tool for NIR imaging of amyloid plaques in a live Caenorhabditis elegans model of AD and in 5× FAD transgenic mice of early amyloid deposition. Our observations indicate that CAQ is promising for providing comprehensive information on neurodegenerative research, thereby promoting a deeper understanding of Alzheimer's pathological processes.
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