[Clinical analysis of 5 cases of endobronchial hamartoma].

Objective: To analyze the clinical manifestations of patients with endobronchial hamartoma(EH),and therefore to improve understanding of the disease. Methods: Data were retrospectively reviewed to describe the clinical characteristics, diagnosis procedures and prognosis of EH, including 5 patients in Beijing Anzhen Hospital, Capital Medical University from Jun 2007 to Feb 2018 and another 159 patients from Chinese and English literatures published after Jan 2000. Results: The five patients, 4 males and 1 female, aged from 46 to 69 years[mean (56±7) years], were diagnosed with EH in our hospital. There was no fever in the 5 cases, cough and expectoration in 4 cases, hemoptysis in 3 cases and asymptomatic in 1 case. Chest CT revealed that the lesions of all 5 cases were located in the right bronchial tube; 3 as high-density endobronchial mass, 1 as low-density mass, 1 as mixed density mass, and 1 as a "popcorn" lesion. Three cases were accompanied by obstructive pneumonia in the distal part of the EH and 2 cases by atelectasis. CT enhanced scan was performed in 5 cases, 2 showing no enhancement and 3 showing mild enhancement. Four cases showed polyposis under bronchoscopy, and 5 cases received bronchoscopic biopsy with 3 pathologically diagnosed as EH. Four of them received lobectomy, while 1 received removal by biopsy forceps, and all were pathologically confirmed as EH. There was no evidence of recurrence in these 5 patents with follow-up. Conclusions: EH was a rare benign bronchial tumor with nonspecific clinical and imaging manifestations. Endobronchial polyposis could be revealed by bronchoscopy, and pathological study is required to confirm the diagnosis.目的： 分析支气管内型错构瘤患者的临床资料，提高临床医生对本病的认识。 方法： 收集2007年6月至2018年2月首都医科大学附属北京安贞医院确诊的5例支气管内型错构瘤病例，并结合2000年1月以后国内外文献报道的病例，对支气管内型错构瘤的临床特点、诊治过程以及预后进行回顾性分析。 结果： 5例患者中，男4例，女1例，年龄为46~69岁，平均（56±7）岁。5例患者均无发热，咳嗽、咳痰4例，咯血3例，1例无临床症状。胸部CT示5例瘤体均位于右侧支气管，3例瘤体为单纯高密度灶，1例为单纯低密度灶，1例为混杂密度灶，瘤体呈"爆米花"样改变1例。5例中3例伴瘤体远端的阻塞性肺炎，2例伴肺不张。5例均行胸部CT增强扫描，3例瘤体轻度强化，2例无强化。5例中4例气管镜下见息肉样肿物。5例均行诊断性活检，病理结果3例明确为支气管内型错构瘤。4例患者行肺叶切除术，1例行气管镜下瘤体切除，5例病理均确诊为支气管内型错构瘤。术后随访时间为6个月至5年，均未见复发。 结论： 支气管内型错构瘤是少见的支气管内良性肿瘤，临床症状及影像学无特异性。气管镜下可见息肉样肿物。病理学是确诊的金标准。.