CD8型
抗原
抗原呈递
免疫疗法
MHC I级
癌症研究
人类白细胞抗原
抗原处理
免疫系统
生物
免疫学
主要组织相容性复合体
细胞毒性T细胞
T细胞
遗传学
体外
作者
Camilla Thuring,Linda Geironson,Kajsa Paulsson
出处
期刊:Anti-cancer Agents in Medicinal Chemistry
[Bentham Science]
日期:2014-08-25
卷期号:14 (8): 1101-1109
被引量:7
标识
DOI:10.2174/1871520614666140825110402
摘要
Human leukocyte antigen class I (HLA-I) molecules present antigenic peptides to cytotoxic CD8+ T cells. Downregulation of peptide:HLA-I complexes is common in tumors and results in tumor immune escape variants. Also molecules involved in the maturation of HLA-I have been demonstrated to be dysregulated in malignant neoplasms. We here set out to investigate the antigen presentation capabilities of a set of 12 glioblastoma multiforme (GBM) tumors based on the expression of HLA-I. Moreover, we analyzed the expression of tapasin, a protein dedicated and essential to HLA-I maturation, as well as the infiltration of CD8+ cells using immunohistochemistry on paraffin-embedded sections. Comparison of different GBMs showed a variation in expression of both HLA-I heavy chain (HC) and tapasin. Interestingly, the expression of tapasin and HLA-I HC correlated significantly (p=0.0002) suggesting tapasin to be a key factor for efficient HLA-I antigen presentation in GBMs. Although no statistically significant correlation between CD8+ cells and survival was found, probably due to a very low number of infiltrating CD8+ cells at the time of surgical resection, both tapasin and HLA-I HC levels significantly correlated with survival. We suggest that analysis of expression of tapasin and/or HLA-I may be of value as prognostic tool for GBM patients, especially when considering immunotherapy. Keywords: Brain tumor, CD8, glioblastoma multiforme, HLA-I, MHC-I, tapasin.
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