微生物群
生物
人体微生物群
西化
队列
粪便
生态学
进化生物学
动物
遗传学
医学
内科学
现代化理论
经济
经济增长
作者
Tanya Yatsunenko,Federico E. Rey,Mark Manary,Indi Trehan,Maria Gloria Dominguez‐Bello,Mónica Contreras,Magda Magris,Glida Hidalgo,Robert N. Baldassano,Andrey P. Anokhin,Andrew C. Heath,Barbara Warner,Jens Reeder,Justin Kuczynski,J. Gregory Caporaso,Catherine Lozupone,Christian L. Lauber,José C. Clemente,Dan Knights,Rob Knight,Jeffrey I. Gordon
出处
期刊:Nature
[Springer Nature]
日期:2012-05-09
卷期号:486 (7402): 222-227
被引量:6446
摘要
Gut microbial communities represent one source of human genetic and metabolic diversity. To examine how gut microbiomes differ among human populations, here we characterize bacterial species in fecal samples from 531 individuals, plus the gene content of 110 of them. The cohort encompassed healthy children and adults from the Amazonas of Venezuela, rural Malawi and US metropolitan areas and included mono- and dizygotic twins. Shared features of the functional maturation of the gut microbiome were identified during the first three years of life in all three populations, including age-associated changes in the genes involved in vitamin biosynthesis and metabolism. Pronounced differences in bacterial assemblages and functional gene repertoires were noted between US residents and those in the other two countries. These distinctive features are evident in early infancy as well as adulthood. Our findings underscore the need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization. The human gut microbiome from a large cohort of more than 500 indivduals living on three continents with three distinct cultures is analysed, emphasizing the effect of host age, diet and environment on the composition and functional repertoire of fecal microbiota. The human gut microbiome is thought to be shaped by both host diet and genetics. Using a sample set of more than 500 individuals belonging to around 150 families from three different countries, Yatsunenko et al. analyse the impact of both factors on the composition and functional repertoire of the fecal microbiota.
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