Transdermal delivery is constantly challenging system for the drug molecule to encroach appearance of its therapeutic action because of many features of skin. In this review we cover different aspect of transdermal delivery along with its evaluation as wel l as current advancement in transdermal drug delivery system. We also try to cover different generation of transdermal delivery as like iontophoresis, sonophoresis, electroporation, microneedles, magnetophoresis, photomechanical waves,