Oral Immunotherapy of Recurrent Urinary Tract Infections: A Double-Blind Placebo-Controlled Multicenter Study

No AccessJournal of Urology1 Sep 1993Oral Immunotherapy of Recurrent Urinary Tract Infections: A Double-Blind Placebo-Controlled Multicenter Study C.C. Schulman, A. Corbusier, H. Michiels, and H.J. Taenzer C.C. SchulmanC.C. Schulman , A. CorbusierA. Corbusier , H. MichielsH. Michiels , and H.J. TaenzerH.J. Taenzer View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)35648-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail We treated 166 patients suffering from recurrent urinary tract infections under double-blind conditions for 3 months with 1 capsule daily of either the immunostimulating bacterial extract (85) or a placebo (81), followed by a 3-month observation period without the test drugs. The bacterial extract exerted a significant beneficial curative action and long-term consolidative effect on the frequency of recurrent urinary tract infections with marked improvements in the characteristic signs and symptoms. It was significantly superior to placebo for the majority of the assessed parameters: number of recurrent urinary tract infections, bacteriuria, leukocyturia, erythrocyturia, nitrituria, albuminuria and casts in urine. Consumption of antibiotics, chemotherapeutics, urinary antiseptics or disinfectants was significantly less under active drug therapy compared to placebo. Tolerance was good with only 2 side effects reported in 2 patients (2%) in the active group compared to 11 among 5 (6%) in the placebo group. Therefore, the bacterial extract can be considered an efficient and well tolerated drug for the treatment of urinary tract infections, and their accompanying signs and symptoms, as well as for decreasing the risk of recurrences and the need for antibiotics and other antibacterial drugs. © 1993 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byBeerepoot M, Geerlings S, van Haarst E, van Charante N and ter Riet G (2013) Nonantibiotic Prophylaxis for Recurrent Urinary Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsJournal of Urology, VOL. 190, NO. 6, (1981-1989), Online publication date: 1-Dec-2013.Uehling D, Hopkins W, Balish E, Xing Y and Heisey D (2018) Vaginal Mucosal Immunization for Recurrent Urinary Tract Infection: Phase II Clinical TrialJournal of Urology, VOL. 157, NO. 6, (2049-2052), Online publication date: 1-Jun-1997.Uehling D, Hopkins W, Dahmer L and Balish E (2018) Phase I Clinical Trial of Vaginal Mucosal Immunization for Recurrent Urinary Tract InfectionJournal of Urology, VOL. 152, NO. 6 Part 2, (2308-2311), Online publication date: 1-Dec-1994. Volume 150Issue 3September 1993Page: 917-921 Advertisement Copyright & Permissions© 1993 by The American Urological Association Education and Research, Inc.Keywordsrecurrencebacteriaurinary tract infectionsplacebosimmunotherapyMetricsAuthor Information C.C. Schulman More articles by this author A. Corbusier More articles by this author H. Michiels Current address: Urology Department, Heilig-Hartziekenhuis, Leuven, Belgium. More articles by this author H.J. Taenzer Current address: 2788768, Praket. Arzt, Richard-Wagner-Str. 1-3, 5000 Koln 40, Germany. More articles by this author Expand All Advertisement PDF downloadLoading ...