MMP1型
卵巢癌
癌症研究
间皮
间皮细胞
转移
转录组
细胞凋亡
癌细胞
生物
旁分泌信号
癌症
医学
病理
内科学
基因表达
基因
受体
生物化学
作者
Akira Yokoi,Yusuke Yoshioka,Yusuke Yamamoto,Masatoshi Ishikawa,Shoichiro Ikeda,Tomoyasu Kato,Tohru Kiyono,Fumitaka Takeshita,Hiroaki Kajiyama,Fumitaka Kikkawa,Takahiro Ochiya
摘要
Advanced ovarian cancers are highly metastatic due to frequent peritoneal dissemination, resulting in dismal prognosis. Here we report the functions of cancer-derived extracellular vesicles (EVs), which are emerging as important mediators of tumour metastasis. The EVs from highly metastatic cells strongly induce metastatic behaviour in moderately metastatic tumours. Notably, the cancer EVs efficiently induce apoptotic cell death in human mesothelial cells in vitro and in vivo, thus resulting in the destruction of the peritoneal mesothelium barrier. Whole transcriptome analysis shows that MMP1 is significantly elevated in mesothelial cells treated with highly metastatic cancer EVs and intact MMP1 mRNAs are selectively packaged in the EVs. Importantly, MMP1 expression in ovarian cancer is tightly correlated with a poor prognosis. Moreover, MMP1 mRNA-carrying EVs exist in the ascites of cancer patients and these EVs also induce apoptosis in mesothelial cells. Our findings elucidate a previously unknown mechanism of peritoneal dissemination via EVs.
科研通智能强力驱动
Strongly Powered by AbleSci AI