Neuroprotective Fatty Acids from the Stem Bark of Sorbus commixta

Abstract Phytochemical investigation of the bark from the stems of Sorbus commixta led to the isolation and characterization of a new fatty acid, sorcomic acid ( 1 ), along with nine known analogues ( 2 – 10 ). The structure of the new compound ( 1 ) was determined through NMR ( 1 H and 13 C NMR, HSQC, HMBC, and NOESY), MS, and specific optical rotation. The known compounds ( 2 – 10 ) were identified by comparison of their spectroscopic data with those in the literature. The biological activities of all the isolated compounds ( 1 – 10 ) were evaluated: compounds 1 , 5 , and 7 potently induced NGF secretion from C6 glioma cells (233.40 ± 12.82, 194.40 ± 8.05, and 185.74 ± 10.25 %, respectively) and compound 10 reduced NO levels with an IC 50 value of 71.25 μM in murine microglia BV2 cells stimulated by LPS.