Cryogenic 3D printing of modified polylactic acid scaffolds with biomimetic nanofibrous architecture for bone tissue engineering

聚乳酸 脚手架 组织工程 材料科学 粘附 3D打印 生物矿化 生物医学工程 纳米技术 化学工程 复合材料 聚合物 工程类
作者
Dian Xu,Shunyu Chen,Chunling Xie,Qingshuang Liang,Xiufeng Xiao
出处
期刊:Journal of Biomaterials Science-polymer Edition [Taylor & Francis]
卷期号:33 (4): 532-549 被引量:13
标识
DOI:10.1080/09205063.2021.1997210
摘要

The individualized polylactic acid (PLA) scaffolds fabricated by 3D printing technique have a good application prospect in the bone tissue engineering field. However, 3D printed PLA scaffold mainly manufactured by using a Fused Deposition Modelling fabrication technique (FDM) has some disadvantages, such as having smooth surface, strong hydrophobicity, poor cell adhesion, undesirable bioactivity, the degradation and deterioration at a high temperature triggering an inflammatory response. In this work, the aminated modified polylactic acid nanofibrous scaffold prepared by cryogenic 3D printing technology is designed to provide a feasible countermeasure to solve the key problems existing at present. The prepared scaffolds were fully characterized in terms of physico-chemical and morphological analyses, and the collected results revealed that the using of the cryogenic 3D printing technology can effectively avoid the degradation and deterioration of PLA at a high temperature required by FDM technique and promote the formation of nanofibrous structures. The in vitro tests with MC3T3-E1 cells confirmed that the cell-responsive biomimetic fibrous architecture and improved hydrophilicity due to the introduction of hydrophilic active amino groups provided a bioactive interface for cell adhesion and growth. Meanwhile, the active amino groups introduced by ammonolysis reaction can act as active sites for biomineralization. Thus, the as-prepared scaffolds may hold great potential for bone tissue engineering applications.
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