Engineered Exosomes-Based Photothermal Therapy with MRI/CT Imaging Guidance Enhances Anticancer Efficacy through Deep Tumor Nucleus Penetration

微泡 光热治疗 体内 纳米医学 癌症研究 体外 医学 纳米囊 免疫原性 纳米颗粒 化学 材料科学 纳米技术 小RNA 生物化学 生物技术 基因 生物
作者
Min Yang,Xiaohui Wang,Fang Pu,Ying Liu,Jia Guo,Shuzhuo Chang,Guo-Ying Sun,Yinghua Peng
出处
期刊:Pharmaceutics [Multidisciplinary Digital Publishing Institute]
卷期号:13 (10): 1593-1593 被引量:3
标识
DOI:10.3390/pharmaceutics13101593
摘要

Exosomes, as natural nanovesicles, have become a spotlight in the field of cancer therapy due to their reduced immunogenicity and ability to overcome physiological barriers. However, the tumor targeting ability of exosomes needs to be improved before its actual application. Herein, a multiple targeted engineered exosomes nanoplatform was constructed through rare earth element Gd and Dy-doped and TAT peptide-modified carbon dots (CDs:Gd,Dy-TAT) encapsulated into RGD peptide engineered exosomes (Exo-RGD), which were used to enhance the effect of cancer imaging diagnosis and photothermal therapy. In vitro and in vivo experiments showed that the resulting CDs:Gd,Dy-TAT@Exo-RGD could effectively accumulate at cancer site with an increased concentration owing to the targeting peptides modification and exosomes encapsulation. The tumor therapy effects of mice treated with CDs:Gd,Dy-TAT@Exo-RGD were heightened compared with mice from the CDs:Gd,Dy control group. After intravenous injection of CDs:Gd,Dy-TAT@Exo-RGD into tumor-bearing mice, the temperature of tumors rose to above 50 °C under NIR irradiation and the localized hyperpyrexia induced by CDs could remarkably ablate tumors. The survival rate of the mice was 100% after 60 days. In addition, the CDs:Gd,Dy-TAT@Exo-RGD exhibited higher MRI/CT imaging contrast enhancement of tumor sites than that of CDs:Gd,Dy. Our study identified that engineered exosomes are a powerful tool for encapsulating multiple agents to enhance cancer theranostic efficiency and provide insight into precise personalized nanomedicine.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
醉熏的行云完成签到 ,获得积分10
1秒前
FashionBoy应助momucy采纳,获得10
1秒前
3秒前
6秒前
慕青应助鳗鱼中心采纳,获得10
7秒前
8秒前
10秒前
天天快乐应助misa采纳,获得20
10秒前
10秒前
毛竹完成签到,获得积分10
12秒前
13秒前
13秒前
天坑专业战神完成签到,获得积分10
13秒前
14秒前
15秒前
吃的饭广泛应助神勇的荟采纳,获得10
16秒前
慕青应助纯真沛儿采纳,获得20
17秒前
知知发布了新的文献求助10
17秒前
ruqayyah发布了新的文献求助30
18秒前
fuje发布了新的文献求助10
19秒前
鳗鱼中心发布了新的文献求助10
19秒前
量子星尘发布了新的文献求助10
20秒前
22秒前
23秒前
24秒前
请问哈完成签到 ,获得积分10
26秒前
小魏完成签到,获得积分20
26秒前
李健应助知知采纳,获得10
27秒前
27秒前
方忆丹完成签到,获得积分10
28秒前
28秒前
小二郎应助薛薛薛采纳,获得50
29秒前
29秒前
张博洋发布了新的文献求助10
29秒前
长情绿凝发布了新的文献求助10
30秒前
乐瑶发布了新的文献求助10
30秒前
31秒前
31秒前
32秒前
高分求助中
(禁止应助)【重要!!请各位详细阅读】【科研通的精品贴汇总】 10000
Plutonium Handbook 4000
International Code of Nomenclature for algae, fungi, and plants (Madrid Code) (Regnum Vegetabile) 1500
Functional High Entropy Alloys and Compounds 1000
Building Quantum Computers 1000
Social Epistemology: The Niches for Knowledge and Ignorance 500
优秀运动员运动寿命的人文社会学因素研究 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4227062
求助须知:如何正确求助?哪些是违规求助? 3760675
关于积分的说明 11821115
捐赠科研通 3421655
什么是DOI,文献DOI怎么找? 1877841
邀请新用户注册赠送积分活动 931059
科研通“疑难数据库(出版商)”最低求助积分说明 838961