HMGB1
败血症
炎症
全身炎症反应综合征
医学
免疫学
免疫系统
先天免疫系统
感染性休克
器官功能障碍
作者
Chao Deng,Lin Zhao,Zhi Yang,Jiajia Shang,Changyu Wang,Mingzhi Shen,Shuai Jiang,Tian Li,Wencheng Di,Ying Chen,Li He,Ye-Dong Cheng,Yang Yang
标识
DOI:10.1038/s41401-021-00676-7
摘要
High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that is present in almost all cells and regulates the activity of innate immune responses in both intracellular and extracellular settings. Current evidence suggests that HMGB1 plays a pivotal role in human pathological and pathophysiological processes such as the inflammatory response, immune reactions, cell migration, aging, and cell death. Sepsis is a systemic inflammatory response syndrome (SIRS) that occurs in hosts in response to microbial infections with a proven or suspected infectious etiology and is the leading cause of death in intensive care units worldwide, particularly in the aging population. Dysregulated systemic inflammation is a classic characteristic of sepsis, and suppression of HMGB1 may ameliorate inflammation and improve patient outcomes. Here, we focus on the latest breakthroughs regarding the roles of HMGB1 in sepsis and sepsis-related organ injury, the ways by which HMGB1 are released, and the signaling pathways and therapeutics associated with HMGB1. This review highlights recent advances related to HMGB1: the regulation of HMBG1 might be helpful for both basic research and drug development for the treatment of sepsis and sepsis-related organ injury.
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