Biosynthesis and Hypoglycemic Potential of Chitosan Nano-selenium In Experimentally Induced Diabetic In Rats

The present study investigated the effects of chitosan selenium nanoparticles (CTS-SeNPs) at a dose of 2 mg/kg body weight in streptozotocin (STZ) induced diabetes in rat model at a dose of 50 mg/kg body weight.Rats administered SeNPs orally in normal and experimentally induced diabetic rats for 35 days and glibenclamide (Glib) at a dose rate of 20 mg/kg was used as a reference drug.Blood samples were collected at the end of the experiment.Administration of SeNPs that was significantly decreased blood glucose levels and enhanced serum insulin concentration, Results showed a decrease in liver function enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST), all groups' showed nonsignificant changes in serum creatinine levels, decrease cardiac function enzymes creatine kinase-MB (CK-MB).Results also showed a significant decrease in the activity of α-amylase.Also, Glib administration exhibited a significant improvement in diabetic animals after 35 days of treatment.This study suggests that SeNPs capped with chitosan can alleviate hyperglycemia and showing synergistic effect in STZ-induced diabetic rats and this protection may be possibly by eliciting or SeNPs showed enhancement of the elimination of the diabetes-induced oxidative stress injuries.