间充质干细胞
移植
干细胞
再生医学
免疫原性
免疫学
医学
免疫系统
细胞疗法
炎症
干细胞疗法
癌症研究
再生(生物学)
多能干细胞
生物
病理
细胞生物学
祖细胞
内科学
作者
Songyue Lou,Yongtao Duan,Huizong Nie,Xujie Cui,Jiang Du,Yongfang Yao
出处
期刊:Biochimie
[Elsevier]
日期:2021-06-01
卷期号:185: 9-21
被引量:32
标识
DOI:10.1016/j.biochi.2021.03.003
摘要
Mesenchymal stem cells (MSCs) are multipotent stem cells. In addition to the capacity for self-renewal and multipotential differentiation, MSCs also have the following characteristics. MSCs can exert immunomodulatory functions through interaction with innate or adaptive immune cells, MSCs with poor immunogenicity can be used for allogeneic transplantation, and MSCs can “home” to inflammation and tumour sites. Based on these biological properties, MSCs demonstrate broad clinical application prospects in the treatment of tissue injury, autoimmune diseases, transplantation, cancer and other inflammation-related diseases. In this review we describe the biological characteristics of MSCs and discuss the research advances of MSCs in regenerative medicine, immunomodulation, oncology, and COVID-19, to fully understand the range of diseases in which MSC therapy may be beneficial
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