埃博拉病毒
免疫系统
先天免疫系统
免疫学
疾病
获得性免疫系统
生物
病毒
病毒学
医学
病理
作者
Goutam Banerjee,Kamal Shokeen,Nilanjan Chakraborty,Saumya Agarwal,Arindam Mitra,Sachin Kumar,Pratik Banerjee
标识
DOI:10.1016/j.coph.2021.07.004
摘要
Ebola virus disease targets and destroys immune cells, including macrophages and dendritic cells, leading to impairment of host response. After infection, a combination of strategies including alteration and evasion of immune response culminating in a strong inflammatory response can lead to multi-organ failure and death in most infected patients. This review discusses immune response dynamics, mainly focusing on how Ebola manipulates innate and adaptive immune responses and strategizes to thwart host immune responses. We also discuss the challenges and prospects of developing therapeutics and vaccines against Ebola.
科研通智能强力驱动
Strongly Powered by AbleSci AI