功能性电刺激
工件(错误)
微电极
刺激
神经假体
脑-机接口
多电极阵列
计算机科学
生物医学工程
运动皮层
信号(编程语言)
电生理学
脑电图
神经科学
电极
计算机视觉
医学
心理学
化学
程序设计语言
物理化学
作者
Daniel R. Young,Francis R. Willett,William D. Memberg,Brian Murphy,Benjamin L. Walter,Jennifer A. Sweet,Jonathan P. Miller,Leigh R. Hochberg,Robert F. Kirsch,A Bolu Ajiboye
出处
期刊:Journal of Neural Engineering
[IOP Publishing]
日期:2018-01-25
卷期号:15 (2): 026014-026014
被引量:26
标识
DOI:10.1088/1741-2552/aa9ee8
摘要
Functional electrical stimulation (FES) is a promising technology for restoring movement to paralyzed limbs. Intracortical brain-computer interfaces (iBCIs) have enabled intuitive control over virtual and robotic movements, and more recently over upper extremity FES neuroprostheses. However, electrical stimulation of muscles creates artifacts in intracortical microelectrode recordings that could degrade iBCI performance. Here, we investigate methods for reducing the cortically recorded artifacts that result from peripheral electrical stimulation.One participant in the BrainGate2 pilot clinical trial had two intracortical microelectrode arrays placed in the motor cortex, and thirty-six stimulating intramuscular electrodes placed in the muscles of the contralateral limb. We characterized intracortically recorded electrical artifacts during both intramuscular and surface stimulation. We compared the performance of three artifact reduction methods: blanking, common average reference (CAR) and linear regression reference (LRR), which creates channel-specific reference signals, composed of weighted sums of other channels.Electrical artifacts resulting from surface stimulation were 175 × larger than baseline neural recordings (which were 110 µV peak-to-peak), while intramuscular stimulation artifacts were only 4 × larger. The artifact waveforms were highly consistent across electrodes within each array. Application of LRR reduced artifact magnitudes to less than 10 µV and largely preserved the original neural feature values used for decoding. Unmitigated stimulation artifacts decreased iBCI decoding performance, but performance was almost completely recovered using LRR, which outperformed CAR and blanking and extracted useful neural information during stimulation artifact periods.The LRR method was effective at reducing electrical artifacts resulting from both intramuscular and surface FES, and almost completely restored iBCI decoding performance (>90% recovery for surface stimulation and full recovery for intramuscular stimulation). The results demonstrate that FES-induced artifacts can be easily mitigated in FES + iBCI systems by using LRR for artifact reduction, and suggest that the LRR method may also be useful in other noise reduction applications.
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