述情障碍
认知
情感(语言学)
心理学
扣带回前部
平衡(能力)
谷氨酸受体
联想(心理学)
神经科学
医学
临床心理学
内科学
受体
心理治疗师
沟通
作者
Anne Kühnel,Annekathrin Widmann,Lejla Čolić,Luisa Herrmann,Liliana Ramona Demenescu,A L Leutritz,M Li,Simone Grimm,Tobias Nolte,Peter Fonagy,Martin Walter
标识
DOI:10.1017/s0033291719001806
摘要
Abstract Background Previous research showed that automatic emotion regulation is associated with activation of subcortical areas and subsequent feedforward processes to cortical areas. In contrast, cognitive awareness of emotions is mediated by negative feedback from cortical to subcortical areas. Pregenual anterior cingulate cortex (pgACC) is essential in the modulation of both affect and alexithymia. We considered the interplay between these two mechanisms in the pgACC and their relationship with alexithymia. Method In 68 healthy participants (30 women, age = 26.15 ± 4.22) we tested associations of emotion processing and alexithymia with excitation/inhibition (E/I) balance represented as glutamate (Glu)/GABA in the pgACC measured via magnetic resonance spectroscopy in 7 T. Results Alexithymia was positively correlated with the Glu/GABA ratio ( N = 41, p = 0.0393). Further, cognitive self-awareness showed an association with Glu/GABA ( N = 52, p = 0.003), which was driven by a correlation with GABA. In contrast, emotion regulation was only correlated with glutamate levels in the pgACC ( N = 49, p = 0.008). Conclusion Our results corroborate the importance of the pgACC as a mediating region of alexithymia, reflected in an altered E/I balance. Furthermore, we could specify that this altered balance is linked to a GABA-related modulation of cognitive self-awareness of emotions.
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