化学
钯
催化作用
吡啶
烷基
酒
基质(水族馆)
组合化学
苯乙酸
有机化学
药物化学
海洋学
地质学
作者
Hui Xu,Min Liu,Lingjun Li,Ya-Fang Cao,Jin–Quan Yu,Hui‐Xiong Dai
出处
期刊:Organic Letters
[American Chemical Society]
日期:2019-06-11
卷期号:21 (12): 4887-4891
被引量:54
标识
DOI:10.1021/acs.orglett.9b01784
摘要
Palladium-catalyzed meta-selective C-H deuteration of a series of substrates, including phenylacetic acids, hydrocinnamic acid, benzylphosphonate, benzylsulfonate, and benzyl and phenyl ethyl alcohol ester, is developed by using a pyridine-based directing template. The template is installed into the substrate through a practical ester linkage. Under mild reaction conditions, a variety of phenylacetic acids containing alkyl, methoxyl, and halo substituents are compatible in the reaction, resulting in high levels of D-incorporation at the meta position.
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