化学
立体化学
真菌
细胞毒性
IC50型
抗菌剂
十氢萘
细胞培养
生物化学
体外
有机化学
植物
生物
遗传学
催化作用
作者
Yulin Sun,Jie Wang,Yifei Wang,Xiaoyong Zhang,Xu‐Hua Nong,Maoyun Chen,Xin‐Ya Xu,Shu‐Hua Qi
出处
期刊:Tetrahedron
[Elsevier]
日期:2015-12-01
卷期号:71 (49): 9328-9332
被引量:23
标识
DOI:10.1016/j.tet.2015.10.010
摘要
Trichobotrysins A–F (1–6), a class of new tetramic acid derivatives with a decalin ring, were characterized from the culture of Trichobotrys effuse DFFSCS021 derived from the deep sea sediment collected from the South China Sea. Their structures were elucidated by extensive spectroscopic analysis. Compounds 1, 2, and 4 exhibited significant selective cytotoxicity against human carcinoma KG-1a cell line with IC50 values of 5.44, 8.97, and 6.16 μM, and obvious antiviral activity towards HSV-1 with IC50 values of 3.08, 9.37, and 3.12 μM, respectively. This is the first time to report the anti-HSV-1 activity of this type of compounds.
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