脂肪生成
脂肪组织
基质血管部分
脂肪细胞
旁分泌信号
细胞生物学
间质细胞
生物
脂肪组织巨噬细胞
干细胞
人口
内分泌学
内科学
细胞分化
白色脂肪组织
癌症研究
生物化学
医学
受体
环境卫生
基因
作者
Petra Schwalie,Hua Dong,Magda Zachara,Julie Russeil,Daniel Alpern,Nassila Akchiche,Christian Caprara,Wenfei Sun,Kai-Uwe Schlaudraff,Gianni Soldati,Christian Wolfrum,Bart Deplancke
出处
期刊:Nature
[Springer Nature]
日期:2018-06-20
卷期号:559 (7712): 103-108
被引量:327
标识
DOI:10.1038/s41586-018-0226-8
摘要
Adipocyte development and differentiation have an important role in the aetiology of obesity and its co-morbidities1,2. Although multiple studies have investigated the adipogenic stem and precursor cells that give rise to mature adipocytes3-14, our understanding of their in vivo origin and properties is incomplete2,15,16. This is partially due to the highly heterogeneous and unstructured nature of adipose tissue depots17, which has proven difficult to molecularly dissect using classical approaches such as fluorescence-activated cell sorting and Cre-lox lines based on candidate marker genes16,18. Here, using the resolving power of single-cell transcriptomics19 in a mouse model, we reveal distinct subpopulations of adipose stem and precursor cells in the stromal vascular fraction of subcutaneous adipose tissue. We identify one of these subpopulations as CD142+ adipogenesis-regulatory cells, which can suppress adipocyte formation in vivo and in vitro in a paracrine manner. We show that adipogenesis-regulatory cells are refractory to adipogenesis and that they are functionally conserved in humans. Our findings point to a potentially critical role for adipogenesis-regulatory cells in modulating adipose tissue plasticity, which is linked to metabolic control, differential insulin sensitivity and type 2 diabetes.
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