电泳剂
级联
化学
芳基
草酸盐
酒
组合化学
偶联反应
催化作用
联轴节(管道)
有机化学
药物化学
材料科学
色谱法
冶金
烷基
作者
Nicholas A. Weires,Yuriy Slutskyy,Larry E. Overman
标识
DOI:10.1002/anie.201903353
摘要
Abstract An alkoxycarbonyl radical cyclization–cross‐coupling cascade has been developed that allows functionalized γ‐butyrolactones to be prepared in one step from simple tertiary alcohol‐derived homoallylic oxalate precursors. The reaction succeeds with aryl and vinyl electrophiles and is compatible with heterocyclic fragments in both coupling partners. This chemistry allows for the rapid construction of spirolactones, which are of interest in drug discovery endeavors.
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