医学
多囊卵巢
体质指数
产科
妊娠期糖尿病
怀孕
体重增加
肥胖
人口
混淆
小于胎龄
质量指数
荟萃分析
出生体重
妊娠期
内科学
胰岛素抵抗
环境卫生
体重
生物
遗传学
作者
Mahnaz Bahri Khomami,Anju E. Joham,Jacqueline Boyle,Terhi Piltonen,Chavy Arora,Michael Silagy,Marie Misso,Helena Teede,Lisa Moran
摘要
Summary Polycystic ovary syndrome (PCOS) is associated with worsened pregnancy and infant outcomes, higher body mass index (BMI), and longitudinal weight gain. Despite most of the clinical features of PCOS being risk factors for worsened infant outcomes in the general population, their impact on infant outcomes in PCOS is unknown. We aimed to investigate the association of PCOS with infant outcomes considering maternal adiposity, other known risk factors, and potential confounders. The meta‐analyses included 42 studies in 7041 women with PCOS and 63 722 women without PCOS. PCOS was associated with higher gestational weight gain (GWG) and with higher preterm birth and large for gestational age and with lower birth weight with this association varying by geographic continent, PCOS phenotypes, and study quality. However, PCOS was associated with none of these outcomes on BMI‐matched studies. Gestational diabetes was significantly associated with an increased preterm birth on meta‐regression. We report for the first time that GWG is higher in PCOS. Infant outcomes vary by geographic continent and study quality but are similar in BMI‐matched women with and without PCOS. This suggests that infant outcomes in PCOS may be related to maternal obesity. These novel findings warrant future studies in PCOS investigating screening and management of infant outcomes with consideration of maternal obesity.
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