四苯硼酸钠
柠檬酸钠
四苯硼酸盐
化学
凝血酶原时间
色谱法
钠
抗凝血酶
部分凝血活酶时间
凝结
纤维蛋白原
内科学
医学
生物化学
病理
肝素
膜
离子
有机化学
作者
Ronda A. Crist,Kathie Gibbs,George M. Rodgers,Kristi J. Smock
出处
期刊:Laboratory Hematology
[Carden Jennings Publishing Co.]
日期:2009-11-18
卷期号:17 (3): 22-26
被引量:15
摘要
Coagulation testing is performed with citrate-treated plasma. Samples submitted in other anticoagulants, such as EDTA, should not be tested. We aimed to evaluate the effects of EDTA on routine and specialized coagulation tests and to establish sodium tetraphenylborate testing as a quick and reliable method to identify EDTA-treated plasma samples. We performed the following measurements on citrateand EDTA-treated plasma samples from 10 healthy volunteers: sodium tetraphenylborate testing, prothrombin time (PT), partial thromboplastin time (PTT), potassium concentration, and functional assays for factors II, V, VII, VIII, IX, X, XI, XII, proteins C and S, and antithrombin. Mean values for citrate- and EDTA-treated plasma were most different for PT, PTT, factors V and VIII, and proteins C and S. Sodium tetraphenylborate testing correctly classified 100% of citratetreated and EDTA-treated samples. We confirm that EDTA has effects on coagulation assays. Sodium tetraphenylborate testing is a quick, simple, and inexpensive method for coagulation laboratories to identify samples erroneously submitted in EDTA.
科研通智能强力驱动
Strongly Powered by AbleSci AI