多面体
生物
细胞生物学
翻译(生物学)
机制(生物学)
基因
杆状病毒科
载体(分子生物学)
遗传学
计算生物学
信使核糖核酸
重组DNA
物理
夜蛾
量子力学
作者
Guanping Chen,Shudi Zhao,Nan Chen,Xiaoxia Wu
出处
期刊:Gene
[Elsevier]
日期:2022-03-01
卷期号:814: 146129-146129
被引量:1
标识
DOI:10.1016/j.gene.2021.146129
摘要
One of the amazing phenomena in the baculovirus life cycle is the hyperexpression of the very late gene, polyhedrin (polh), causing the production of the occlusion bodies where progeny virions are embedded. However, to date, the molecular mechanism underlying its hyperexpression is not completely elucidated. Considering that, in this review, the mechanism responsible for its hyperexpression from the previous studies up to now was comprehensively summarized from three aspects, namely, the structure characteristics of the polh promoter and transcription regulation, the structure and translation regulation of the polh mRNA, and especially the regulators that influence the expression of polh gene. Moreover, this review will help us obtain a better understanding about the hyperexpression of polh, and also provide guidance for improving the expression efficiency of the foreign proteins by adopting the baculovirus expression vector system.
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