CFD–PBE Model and Simulation of Continuous Antisolvent Crystallization in an Impinging Jet Crystallizer with a Multiorifice at Different Positions

In this study, a comprehensive model which combines CFD and the population balance equation (PBE) was utilized to simulate the paracetamol continuous antisolvent crystallization. PBE was discretized using a high-resolution scheme and solved with the Eulerian multiphase model. The results indicated that the CFD–PBE model could successfully simulate the fluid dynamics, mass transfer, and crystal size distribution in the crystallizer. Based on the previously proposed multiorifice impinging jet crystallizer, an impinging jet crystallizer with a multiorifice at different axial positions was designed and studied in detail. The effects of different operating conditions on the mixing and crystallization were analyzed and discussed. The results obtained in this work can be used to help the design and optimization of the impinging jet crystallizer with a multiorifice at different positions.