光热治疗
MMP9公司
基质金属蛋白酶
肿瘤微环境
化学
癌症研究
药物输送
磁共振成像
纳米技术
生物医学工程
材料科学
医学
下调和上调
肿瘤细胞
生物化学
放射科
基因
作者
An Chen,Hongwei Lu,Rong Cao,Yan Zhu,Yumeng Li,Renbin Ge,Siruo Zhang,Yulin Li,Lan Xiao,Su Li,Jianhua Zhao,Honggang Hu,Zhongling Wang
出处
期刊:Nano Today
[Elsevier]
日期:2022-08-01
卷期号:45: 101524-101524
被引量:14
标识
DOI:10.1016/j.nantod.2022.101524
摘要
Quantifying bio-targeted markers in the tumor microenvironment through non-invasive approaches remains challenging. In this study, a novel matrix metalloproteinase-9 (MMP9) responsive nanoplatform ([email protected]/DOX, PMPSD) with transformable magnetic resonance property is designed for quantitative tumor bioimaging and synergetic chemo-photothermal therapy. The nanoplatform acts as a T2 contrast agent in physiological conditions due to the ultrasmall superparamagnetic iron oxide (USPIO) aggregation state, whereas in the tumor microenvironment, the nanoclusters are dissociated by MMP9, thus transforming the nanoplatform into a T1 contrast agent. T1&T2 weighted image and T1&T2 maps are utilized to quantitatively study the correlation between MRI signal changes and MMP9 concentrations and to evaluate MMP9 activity. In addition, the [email protected]/DOX nanoplatform possesses excellent photothermal properties. PMPSD combined with laser irradiation is more effective than single chemo-/photothermal therapy, and up-regulation of the MMP9 level in the tumor can further improve the therapeutic effect. The nanoplatform is of great significance in evaluating disease prognosis and non-invasive monitoring of drug release. The concept reported here provides a creative idea for the non-invasive quantitative study of the tumor microenvironment.
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