微泡
细胞外小泡
癌症
药物输送
癌细胞
癌症治疗
临床试验
医学
癌症研究
计算生物学
生物
生物信息学
化学
细胞生物学
小RNA
生物化学
内科学
基因
有机化学
作者
Salomé Araujo-Abad,Miguel Saceda,Camino de Juan Romero
标识
DOI:10.1016/j.addr.2022.114117
摘要
Extracellular vesicles (EVs) are produced by almost all cell types in vivo or in vitro. Among them, exosomes are small nanovesicles with a lipid bilayer, proteins and RNAs actively involved in cellular communication, suggesting that they may be used both as biomarkers and for therapeutic purposes in diseases such as cancer. Moreover, the idea of using them as drug delivery vehicle arises as a promising field of study. Here, we reviewed recent findings showing the importance of EVs, with special focus in exosomes as biomarkers including the most relevant proteins found in different cancer types and it is discussed the FDA approved tests which use exosomes in clinical practice. Finally, we present an overview of the different chimeric EVs developed in the last few years, demonstrating that they can be conjugate to nanoparticles, biomolecules, cancer drugs, etc., and can be developed for a specific cancer treatment. Additionally, we summarized the clinical trials where EVs are used in the treatment of several cancer types aiming to improve the prognosis of these deadly diseases.
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