Doppler Imaging Assessment of Changes of Blood Flow in Adenomyosis After Higher‐Dose Oxytocin: A Randomized Controlled Trial

Objectives To assess the changes of blood flow in adenomyosis (AM) after higher‐dose oxytocin (OT) in different doses, and to evaluate the safety for patients. Methods A total of 124 patients with AM were randomly divided into 4 groups with continuous intravenous infusion of OT as 0.06, 0.12, 0.24 and 0.36 U/min, respectively. The changes of arteries of AM before and after intravenous infusion of OT were observed by color Doppler ultrasound. The changes of blood flow volume of the artery of AM before and after intravenous infusion of OT were compared among the 4 groups, and the vital signs and adverse drug reactions were monitored during intravenous drip. Results During the trial, no severe adverse reactions occurred and the vital signs of all the patients were stable. Among the 4 groups, it was found that there was a significant difference in the change of blood flow volume of blood artery in AM lesions between 0.06 U/min OT group and the other three groups after intravenous drip of OT ( P < .05), but there was no significant difference in blood flow volume among the three groups ( P > .05), and the difference of adverse drug reactions was statistically significant with the increase of OT dose ( P < .05). Conclusion OT can effectively reduce the blood flow volume of AM lesions, and continuous intravenous infusion of 0.12 U/min OT is an appropriate dose that can not only minimize the blood flow volume but also reduce the incidence of adverse drug reactions.