抗菌剂
化学
细菌
生物相容性材料
抗生素耐药性
抗生素
聚合物
纳米技术
抗菌药物
细菌细胞结构
组合化学
有机化学
生物化学
生物医学工程
材料科学
生物
医学
遗传学
作者
Salauddin Ahmed,Thirunavukkarasu Annamalai,Xuerong Li,Ahmed Seddek,P. K. Teng,Yuk‐Ching Tse‐Dinh,Joong Ho Moon
标识
DOI:10.1021/acs.bioconjchem.8b00057
摘要
Bacterial infections are serious health threats. Emerging drug resistance in bacteria further poses serious challenges to the treatment options involving traditional antibiotics. Antimicrobial polymers disrupt the physical cell membrane integrity of bacteria to address the drug resistance problems. Here, we introduce a conceptually new class of antimicrobial polymers containing positively charged guanylurea backbones for enhanced antimicrobial effects. The initial structure–activity relationship studies demonstrate that poly(guanylurea piperazine)s (PGU-Ps) exhibit excellent antimicrobial activity against different types of bacteria with high selectivity. The new design concept of using a positively charged guanylurea backbone will contribute to the development of future biocompatible, specific, and selective antimicrobial polymers.
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