免疫原性
佐剂
抗原
免疫系统
免疫学
接种疫苗
医学
肠道相关淋巴组织
淋巴系统
胃肠道
免疫
生物
微熔池
内科学
作者
Edna Soares,Fernandes Borges
出处
期刊:Current Drug Delivery
[Bentham Science]
日期:2018-03-27
卷期号:15 (3): 321-330
被引量:11
标识
DOI:10.2174/1567201814666170825153955
摘要
Oral immunization has numerous advantages over parenteral administrations. In addition to ease administration, more effective pathogen elimination on the mucosa before spreading into the blood circulation, constitutes the main benefit. This is particularly true for pathogens that enter the body through the oral route. On the other hand, it is the most challenging administration route for peptides, proteins and recombinant antigens due to gastrointestinal (GI) tract, numerous barriers including the harsh environment and the inherent weak immunogenicity. In addition to the adjuvant properties, polymeric particles arise as the most promising strategy to overcome poor antigen bioavailability/ stability upon oral administration. The Peyer's patches have been considered an important structure of the gut associate lymphoid tissue (GALT) for the initiation of the immune response towards particulate oral antigens.The transport mechanism of both, nano and microparticles across intestinal mucosa, particularly throughout Peyer's patches, is discussed in this review.We provide a short and concise update (last decade) focused on the importance of particle physicochemical properties, M-cell ligands and size-dependent transport and intracellular fate concerning Peyer's patches targeted oral vaccination.
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