细胞外基质
纤维化
肺纤维化
基质(化学分析)
特发性肺纤维化
生物力学
疾病
医学
病理
神经科学
生物
化学
细胞生物学
肺
内科学
解剖
色谱法
作者
Andrew J. Haak,Qi Tan,Daniel J. Tschumperlin
标识
DOI:10.1016/j.matbio.2017.12.004
摘要
The composition and mechanical properties of the extracellular matrix are dramatically altered during the development and progression of pulmonary fibrosis. Recent evidence indicates that these changes in matrix composition and mechanics are not only end-results of fibrotic remodeling, but active participants in driving disease progression. These insights have stimulated interest in identifying the components and physical aspects of the matrix that contribute to cell activation and disease initiation and progression. This review summarizes current knowledge regarding the biomechanics and dynamics of the ECM in mouse models and human IPF, and discusses how matrix mechanical and compositional changes might be non-invasively assessed, therapeutically targeted, and biologically restored to resolve fibrosis.
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