多物理
多细胞生物
电穿孔
生物系统
电场
材料科学
有限元法
机械
电势能
物理
能量(信号处理)
化学
细胞
结构工程
工程类
基因
生物
量子力学
生物化学
作者
Danish Shamoon,S. Lasquellec,Christian Brosseau
摘要
This letter considers the strain energy distribution in cell assemblies. Our scalable model consists of N-core-shell spherical structures modeling biological cells with assumptions based on two fundamental premises. First, we use a finite element in the framework of time-domain to solve for the electrodeformation and cell electroporation when a well-defined electrical stimulus is delivered to a multicellular environment. Second, the strain-stress response of the cell assemblies is characterized by a relaxation time which is much larger than the time constant of the membrane charging. A “switch off” (corresponding to times after electrical pulsing) phenomenon observed in the strain energy signal might provide an interesting discriminant test capable of providing different information on the proximity (coupling) effect between cell and assembly anisotropy depending on the type of electrical stimulus employed. In the explicit examples we study, we learn up to date facts about how the local enhancement of the electric field, deformation of the cell, strain energy, and relative area occupied by the pores are modified by varying the intercellular distance distribution.
科研通智能强力驱动
Strongly Powered by AbleSci AI