自闭症
自闭症谱系障碍
脑功能偏侧化
生物标志物
心理学
神经影像学
听力学
感觉系统
大脑活动与冥想
神经发育障碍
人口
感觉加工
脑电图
神经科学
发展心理学
医学
化学
环境卫生
生物化学
作者
Elena Scaffei,Raffaele Mazziotti,Eugenia Conti,Valeria Costanzo,Sara Calderoni,Andrea Stoccoro,Claudia Carmassi,Raffaella Tancredi,Laura Baroncelli,Roberta Battini
标识
DOI:10.3390/brainsci13060951
摘要
Autism spectrum disorder (ASD) refers to a neurodevelopmental condition whose detection still remains challenging in young females due to the heterogeneity of the behavioral phenotype and the capacity of camouflage. The availability of quantitative biomarkers to assess brain function may support in the assessment of ASD. Functional Near-infrared Spectroscopy (fNIRS) is a non-invasive and flexible tool that quantifies cortical hemodynamic responses (HDR) that can be easily employed to describe brain activity. Since the study of the visual phenotype is a paradigmatic model to evaluate cerebral processing in many neurodevelopmental conditions, we hypothesized that visually-evoked HDR (vHDR) might represent a potential biomarker in ASD females. We performed a case-control study comparing vHDR in a cohort of high-functioning preschooler females with ASD (fASD) and sex/age matched peers. We demonstrated the feasibility of visual fNIRS measurements in fASD, and the possibility to discriminate between fASD and typical subjects using different signal features, such as the amplitude and lateralization of vHDR. Moreover, the level of response lateralization was correlated to the severity of autistic traits. These results corroborate the cruciality of sensory symptoms in ASD, paving the way for the validation of the fNIRS analytical tool for diagnosis and treatment outcome monitoring in the ASD population.
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