肠道菌群
失调
痴呆
疾病
背景(考古学)
肠-脑轴
免疫系统
认知功能衰退
神经科学
冲程(发动机)
生物
免疫学
阿尔茨海默病
医学
生物信息学
内科学
机械工程
古生物学
工程类
作者
María Isabel Cuartero,Alicia García‐Culebras,Carmen Nieto‐Vaquero,Enrique Fraga,Cristina Torres‐López,Jesús M. Pradillo,Ignacio Lizasoaín,Marı́a A. Moro
摘要
Abstract In recent years, increasing evidence suggests that commensal microbiota may play an important role not only in health but also in disease including cerebrovascular disease. Gut microbes impact physiology, at least in part, by metabolizing dietary factors and host‐derived substrates and then generating active compounds including toxins. The purpose of this current review is to highlight the complex interplay between microbiota, their metabolites. and essential functions for human health, ranging from regulation of the metabolism and the immune system to modulation of brain development and function. We discuss the role of gut dysbiosis in cerebrovascular disease, specifically in acute and chronic stroke phases, and the possible implication of intestinal microbiota in post‐stroke cognitive impairment and dementia, and we identify potential therapeutic opportunities of targeting microbiota in this context. LINKED ARTICLES This article is part of a themed issue From Alzheimer's Disease to Vascular Dementia: Different Roads Leading to Cognitive Decline. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v181.6/issuetoc
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