化学
吗啉
环加成
酮
芳基
锌
分子
药物化学
碘
有机化学
组合化学
催化作用
烷基
作者
Zhi‐Cheng Yu,Xiaodong Shen,You Zhou,Jin‐Tian Ma,Xianglong Chen,Lisheng Wang,Yan‐Dong Wu,Yan‐Dong Wu
标识
DOI:10.1021/acs.joc.3c00885
摘要
2-Hydroxy-4-morpholin-2,5-diarylfuran-3(2H)-one derivatives were constructed sequentially using iodine and zinc dust from simple and readily available methyl ketone and morpholine as the starting materials. Under mild conditions, C–C, C–N, and C–O bonds formed in a one-pot synthesis. A quaternary carbon center was successfully constructed, and the active drug fragment morpholine was introduced into the molecule.
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